Professor Natalia Khuri
Department of Computer Science
Wake Forest University
George P. Williams, Jr. Lecture Hall, (Olin 101)
Wednesday, Nov. 6, 2019, at 3:00 PM
There will be a reception in the Olin Lounge at approximately 4 PM following the colloquium. All interested persons are cordially invited to attend.
ABSTRACT
Solute carrier (SLC) transporters – a family of more than 400 membrane-bound proteins facilitating the transport of ions, drugs, and metabolites across biological membranes – have important roles in physiological processes. Several classes of marketed drugs target SLC transporters, and human genetic studies have provided insight into their roles in both rare and common diseases. Recent technological advances in biophysics and chemical biology allow better characterization of SLC pharmacology. We will describe computational approaches and in vitro experiments to study SLC-mediated drug-drug and drug-nutrient interactions with a focus on two intestinal transporters, the organic anion transporting polypeptide OATP2B1 and the thiamine transporter ThTR-2.