Scott L. Diamond, PhD
Arthur E. Humphrey Professor of
Chemical and Biomolecular Engineering
University of Pennsylvania
George P. Williams, Jr. Lecture Hall, (Olin 101)
Wednesday, Dec. 4, 2019, at 3:00 PM
There will be a reception in the Olin Lounge at approximately 4 PM following the colloquium. All interested persons are cordially invited to attend.
ABSTRACT
Excessive bleeding and clotting represent the two extremes of blood function that often concern patients and their doctors. Hundreds of spatiotemporal reactions proceed within activating and aggregating platelets and the polymerizing plasma as blood clots under flow. Microfluidic devices are ideal for recreating transport physics and hemodynamic forces. We have validated several devices to study hemophilia, combinatorial platelet receptor function, drug responses, platelet quorum sensing, and von Willebrand Factor (vWF) assembly in extreme stenotic flows. With multi-scale simulation of reactive blood clotting under flow, it is now possible to predict disease risks using patient-specific hemodynamics and blood biochemistry/pharmacology. This sets the stage for point-of-care microfluidic diagnostics in emerging areas of neonatology, trauma surgery, and angiography.
Biosketch:
Scott L. Diamond, Ph.D. (B.S., Cornell University 1986; Ph.D., Rice University 1990) Dr. Diamond researches biotechnologies in several key areas: endothelial mechanobiology, blood clot dissolving therapies, blood systems biology, nonviral gene therapy, and high throughput drug discovery. He has produced over 230 publications and patents and has served on advisory committees to NSF, NIH, AHA, and NASA, and has consulted extensively for industry and government. Diamond is the recipient of the NSF National Young Investigator Award, the NIH FIRST Award, the American Heart Association Established Investigator Award, the AIChE Allan P. Colburn Award, and the George Heilmeier Excellence in Research Award. Dr. Diamond is an elected Fellow of the Biomedical Engineering Society (BMES) and the American Institute for Medicine and Biological Engineering (AIMBE). Currently, Dr. Diamond is the Director of the Penn Biotechnology Program, with more than 1000 alumni.